NETOSIS PARAMETERS IN PATIENTS WITH SELECTIVE IGA DEFICIENCY

Objective. To study NETosis parameters in patients with selective immunoglobulin A deficiency. Material and methods. We studied the features of peripheral blood 46 (21 males 25 females, mean age 37±12.7 years) a confirmed diagnosis Results. Аctivation (NET30SP, NET30ST, NET150SP NET150ST, р<0.001) was found IgA deficiency relative to comparison group. The maximum degree increase leukocyte observed during short-term incubation cells NET30ST). relationship between level apoptosis neutrophils has been revealed. simultaneous activation superoxide anion production by showed higher incidence combined clinical manifestations compared an isolated (χ2=9.19; р=0.002). Conclusion. This demonstrated that remission infectious inflammatory diseases, ability form extracellular networks combination other reactivity – anion-producing function is increased.